Epigenetic programming of glucose-regulated insulin release
نویسندگان
چکیده
منابع مشابه
Epigenetic programming of glucose-regulated insulin release.
Pancreatic β cells support glucose homeostasis with great precision by matching insulin release to the metabolic needs of the moment. Previous gene-expression analysis indicates that adult β cells not only produce cell-specific proteins, but also repress a small set of housekeeping genes - such as those encoding lactate dehydrogenase A (LDHA), solute transporter MCT1, and hexokinase 1 (HK1) - t...
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Taylor, James T., Luping Huang, Brian M. Keyser, Hean Zhuang, Craig W. Clarkson, and Ming Li. Role of high-voltage-activated calcium channels in glucose-regulated -cell calcium homeostasis and insulin release. Am J Physiol Endocrinol Metab 289: E900–E908, 2005. First published June 14, 2005; doi:10.1152/ajpendo.00101.2005.—Highvoltage-activated (HVA) calcium channels are known to be the primary...
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The molecular mechanisms mediating acute regulation of insulin release by glucose are partially known. The process involves at least two pathways that can be discriminated on basis of their (in)dependence of closure of ATP-sensitive potassium (K+(ATP)) channels. The mechanism of the K+(ATP) channel-independent pathway was proposed to involve cataplerosis, the export of mitochondrial intermediat...
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The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for excitation-contraction coupling; however, a functional role for RyR2 in β cell insulin secretion and diabetes mellitus remains controversial. Here, we took advan...
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The activation of protein kinase B (or Akt) plays a central role in the stimulation of glucose uptake by insulin. Currently, however, numerous questions remain unanswered regarding the role of this kinase in bringing about this effect. For example, we do not know precisely where in the GLUT4 trafficking pathway this kinase acts. Nor do we know which protein substrates are responsible for mediat...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2015
ISSN: 0021-9738
DOI: 10.1172/jci82575